Because of the impairment to the liver detoxification pathways (6 have been identified by biochemist Martin Pall to be common to people with MCS) and the level of “sensitizations” peripheral (e.g. nociceptor sensory nerves) and central to areas of the brain involved in maintaining your survival and processing your emotional and physical pain e.g. limbic region, amygdala, thalamus, etc. that have occurred due to ongoing toxicity, inflammation and stress (TIS), most medications simply increase symptoms or if benefits are gained they are generally at the expense of side effects.
For this reasons most doctors who have a good understanding of MCS and provide treatment (there are not many!) Prefer to take a multi-dimensional “self management” approach based on dietary changes and chemical, stimuli and stress minimization (as promoted by RESHAPE – coming soon to MCSLIVING).
Having said this however, there are some instances where medications are warranted (e.g. if they are life saving) and some that are providing benefits for some people with MCS e.g. Gabapentin (Neurontin) Pregabalin (Lyrica). NNT for these are around 4 which means for every 4 people treated with these medications 1 person will get real improvements of 50% or more whilst the others will get no improvements (or side effects) or short term improvements only due to the placebo effect. The NNH of the these medications is also around 4 which means 25% of people whot take these medications will experience side effects (NNT and NNH are explained further below).
If you choose to take medication be sure to start on a low dose and increase (titrate) slowly under medical supervision as advised for people with Chronic Fatigue Syndrome (CFS) by the Centers of Disease Prevention and Control.
The Centre of Disease Control Says...
To help you or your health advocate (a trusted friend, family member or other who can act on your behalf at times your memory, concentration and decision making is impaired or compromised ) make an informed decision about medications ask your doctor for the NNT and NNH of any medications they may suggest.
the following is from the Freemantle Hospital Pain Medicine Unit
How harmful are the same drugs?
It is important to know that all treatments come with a Placebo (“I will please”) effect. This means that at least some of those being treated will improve, even when given an inert substance.
Refer guide: Medications for use with a Low Phenolic Diet at www.asehaqld.org.au. For a list of medications etc that may be tolerated see Low salicylate Medications: Medications listed as suitable for those with salicylate and amine (Phenolic) sensitivities by the Royal Prince Alfred Hospital Allergy Clinic.
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