The following are tips that helped me alleviate 50 symptoms and reduce my sensitivities a lot.
I am a medical doctor or health practitioner - so these tips are NOT meant to treat or replace proper medical attention

Treatment in my opinion should primarily focus on managing Central Sensitivity and reducing the neurotransmitter glutamine and NMDA activity - hyper excitability, these can significantly contribute to heightened pain, prolonged pain, wide spread pain (allodynia, hyperalgesia, hyperpathia) and hypersensitivity to chemicals, stimuli and stress.

Heightened NMDA activity and glutamine (glutamate) are involved in the self maintaining NO/OONO inflammatory disease cycle postulated by biochemist Dr Martin Pall, it is worsened by what I call Toxicity, inflammation and stress (TIS). It has also been connected to "sensitisation" and "kindling" which may be worsened by continued exposures to triggering substances and stimuli.

Managing environment and reducing exposure to stimuli and chemicals is very important

it can disrupt the kindling process and reduce sensitivities. (I call this the V5 treatment approach- explained at www.50symptoms gone -also found at my blog 50 symptoms gone are product recommendations and other resources you may find helpful)

For some people anticonvulsant medications such as Gabapentin can be helpful

Tricyclics is another option, however as people with MCS generally have quite severe medicine sensitivity these need to be started on low doses and increased slowly under medical supervision to test for tolerance. This is also recommended to people with chronic fatigue syndrome by the Centers for Disease Control and Prevention (CDC)

Supplement protocols like the Neural Protocol promoted by both Dr Grace Ziem and Dr Martin Pall, have proven beneficial for some people with MCS however harmful for others.

For people with more severe phenol-salicylate intolerance they can worsen symptoms and sensitivities. People with more severe phenol-salicylate intolerance and other pharmacological food intolerance (e.g. MSG, aspartame, glutamine, amines) may experience "drug resistant" depression according to Psychiatrist Dr Gordon Parker and may experience very heightened side effects to "psychogenic" drug therapies.

Phenol-Salicylate intolerance and pharmacological food intolerance affects at least 1 in 3 people with CFS and chemical sensitivities quite severely according to Dr Robert Loblaly Director of the RPAH Allergy Unit.

Until phenol-salicylate intolerance is ruled out I personally think it is important to a take a precautionary approach and assume it is a problem as continuing to take agents and eat foods high in phenols-salicylates has been shown to further deplete enzymes (particularly those that affect Phase 2 liver detoxification-sulfation) and increase toxicity . Some supplements more suitable for people with phenol-salicylate intolerance are listed in the RPAH Allergy Unit personal care and hygiene guide for people with scent and chemical sensitivity. Non phenolic supplements such as B12 methylcobalamin, tri-salts and non plant based toxin binders such as charcoal tabs and zeolites (taken at least 1 hr either side of food so as not to interfere with nutrient absorption) have been reported beneficial by many.

For some people detoxification methods such as FIR Sauna Therapy can be useful if engaged in very safely

however, other detoxification methods can be problematic due to enzyme depletion and liver detoxification impairment and are generally not recommended. Detoxification methods that provoke rapid detoxification such as fasting and high quantities of juices are not generally recommended. Very restricted calorie diets, that promote rapid weight loss should also be avoided according to Dr Grace Ziem.

When it comes to Sauna Therapy Dr Sarah Myhill says that short periods of time in the sauna is all that is necessary as most chemicals come out within a few minutes of sweating. After being in the sauna it is also really important to shower and rehydrate with a mineral mix.

Stress Management is also very important

starting with doing what is necessary to get a better nights sleep and learning and practising stress reduction and management techniques such as MINDFULNESS

Your diet can't heal you but it can worsen your symptoms or it can reduce your symptoms

An unhealthy diet can increase inflammation and pain and a healthy diet if not adjusted for food intolerance if applicable (usually is quite a problem for people with MCS) can increase inflammation and pain. The most common type of food intolerance experienced are linked to carbohydrates, sugar and believe it or not fruits and vegetables. MSG and Aspartame should be eliminated from the diet and it is best to also avoid food additives, preservatives and colourings as well. Find out more about Eating Right when you have MCS at www.50symptoms.gone

Managing MCS without support and help (particularly if very severe and disabling) can be quite difficult

if you do not have help and support at home, find support through your local MCS support organisation and on line.

Dr Bradford Recommends that prior to engaging in any form of treatment a number of resources by Dr Grace Ziem should be read

The following is the recommended reading found at his site: patients read the following


LETTER TO PATIENTS: Detailed explanation of Dr. Ziem’s treatment.

NEW PATIENT HEALTH AND ENVIRONMENT HISTORY: Form filled out by Dr. Ziem’s new patients. (Doctors are permitted to adapt and use this form in their own practices.)

Neural Protocol

Glutathione is the body's important antioxidant and detoxifying molecule, needed in higher amounts in chemical injury. Commercial oral forms are not absorbed, but a new oral form, S-acetyl Glutathione, is now available that is absorbed directly into the blood stream (contact me for details).

SpectraCell Comprehensive Nutritional Panel (cultured lymphocytes) testing
Intestinal healing is essential to health
Oral forms of healing substances, and sublingual MethylCobalamine (the active form of B12)

Help your healthcare provider help you better

Note: When it came to Dr Grace Ziem's suggestion her Environmental control plan for the most part was beneficial for me, however, I could not tolerate all her suggestions, and had a lot of trouble with her supplement and dietary guidelines due to having a more severe phenol-salicylate intolerance (problems with herbs and other plant chemicals).

Regardless of what therapies or suggestions you want to try GO LOW AND GO SLOW and test for individual tolerance - No one doctors or persons suggestion will be entirely right for you

People with MCS (like other people with Central Sensitivity Syndromes (CSS)are experiencing many dysregulations of the the autonomic nervous system and enzyme depletions - this significantly reduces tolerances to standard therapies: detoxification, supplements, medicines, psychological and more, particularly if the person is also experiencing more severe cortisol depletion (hypocortisolism) and liver detoxification impairment. The 2 often go together! (Yanick)

This does not mean you cannot be helped or your situation can not be improved, it just means you need to become a good researcher and enter into treatments cautiously and slowly do not just jump in but instead PACE yourself and set SMART goals and create you own individualised Wellness Plan [discussed at 50 symptoms gone] with the help of a trusted Health Professional.


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2. Woolfe, J. Clifford (March 2012) Central sensitization: Implications for the diagnosis and treatment of pain
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